Core Competitive Advantages:

  • Speed
  • Flexibility
  • Scalability
  • Cost Effective



   Additional key advantages of  

   our proprietary larval system

   include:


  •  The tissue heterogeneity of larvae    (compared to the homogeneity of cultured cells) can be a significant advantage for difficult to produce proteins: larvae can out-produce cultured cells by significant margins for many proteins due to involvement of larvae metabolites, enzymes and co-factors from a variety of cell types.


  • High natural lipid content of larvae enables production and purification of many membrane-embedded and membrane-associated recombinant proteins which are not readily produced using other expression systems.


  • Improved post-translational modifications and protein maturation including efficient signal peptide, propeptide cleavage, N-glycosylation and disulfide bonds formation.


  • Ability to form homo and heterodimers and tetramers.







Examples of Proteins Successfully Expressed Using

Baculovirus in Insect Larvae

                                                                             

     Esterases:

        Paraoxonase I (PON-1)

        Prolidases

        Cholinesterase

        Carboxylesterase

        Acetylcholinesterase

        Butyrylcholinesterase

     VLPs & Other Self- Assembling Molecules:

        Norovirus

        Vault

        Parvovirus

        Rotavirus

      Viral Proteins:

        Vaccinia & Variola Viral Antigen

        Hemaglutinnins (Influenza)

        Herpes Simplex Virus 2

        Nucleoprotein (NP1)

        Matrix Protein (M1)

        Neuraminidase

        Ebola Glycoprotein

        SARS Spike Protein

        HIV gp41

        HIV gp120

     Biofuels:

       Cellulase, Hemicellulase

       Beta Glucosidase

       Aldoketoreductase

       Laccase

       Superoxide dismutase

       Catalase                    

     Cytokines, Hormones & Receptors:

       TSH-R (Thyroid Stimulating Hormone-Receptor)

       Human Growth Factor (Dimerized)

       Growth Factors (3)

       Protein Receptors (4)

       Membrane Transport Proteins

       CCL-21

       RAS Effectors

     Other Proteins:

       Invertebrate Immune Proteins

       Kinases

       Phosphatase

       Antimicrobial Peptides

       Flourescent Proteins

       Fusion Proteins

       Cyclins

       Peptidase

       Lipoprotein

       APOE 3

       APOA

       PNGase-F

       IDO1  - Indoleamine 2,3-dioxygenase                                      



 We specialize in those proteins that are difficult to make. Call us today at 703-895-6754.


Powerful Recombinant Protein Expression and Recovery

Protein Recovery, Purification, Analysis

Production of pre-occluded virus - POV

Oral Inoculation and Incubation